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Article

Characterizing human KIF1Bβ motor activity by single-molecule motility assays and Caenorhabditis elegans genetics.

Journal of cell science - 1 Oct 2024

Iguchi Rei, Kita Tomoki, Watanabe Taisei, Chiba Kyoko, Niwa Shinsuke

Abstract excerpt

The axonal transport of synaptic vesicle precursors relies on KIF1A and UNC-104 ortholog motors. In mammals, KIF1Bβ is also responsible for the axonal transport of synaptic vesicle precursors. Mutations in KIF1A and KIF1Bβ lead to a wide range of neuropathies. Although previous studies have revealed the biochemical, biophysical and cell biological properties of KIF1A, and its defects in neurological disorders,...

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Identifiers

PMID: 39279507
DOI: 10.1242/jcs.261783

Genes

KIF1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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