Article

Modeling the motion of disease-associated KIF1A heterodimers

2023-06-22

Abstract excerpt

<h4>ABSTRACT</h4> KIF1A is a member of the kinesin-3 family motor protein that transports synaptic vesicle precursors in axons. Mutations in the Kif1a gene cause neuronal diseases. Most patients are heterozygous and have both mutated and intact KIF1A alleles, suggesting that heterodimers composed of wild-type KIF1A and mutant KIF1A are likely involved in pathogenesis. In this study, we propose mathematical model...

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Literature Corpus work: 83a1dd52-5037-5c23-b081-cb1e26c75482
DOI: 10.1101/2023.06.22.546060

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