Article

Genetic drift from the out-of-Africa bottleneck leads to biased estimation of genetic architecture and selection

2020-08-17

Abstract excerpt

Most complex traits evolved in the ancestors of all modern humans and have been under negative or balancing selection to maintain the distribution of phenotypes observed today. Yet all large studies mapping genomes to complex traits occur in populations that have experienced the Out-of-Africa bottleneck. Does this bottleneck affect the way we characterise complex traits? We demonstrate using the 1000 Genomes datas...

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Literature Corpus work: 89d39d36-bcc9-5039-8977-48e37e0dae6b
DOI: 10.1101/2020.08.17.254110

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