Article
Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2016
Henn Brenna M, Botigué Laura R, Peischl Stephan, Dupanloup Isabelle, Lipatov Mikhail, Maples Brian K, Martin Alicia R, Musharoff Shaila, Cann Howard, Snyder Michael P, Excoffier Laurent, Kidd Jeffrey M, Bustamante Carlos D
Abstract excerpt
The Out-of-Africa (OOA) dispersal ∼ 50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase of mutational load in populations undergoing serial founder effects during range expansions. To test this hypothesis, we have sequenced full genomes and high-coverage exomes from seven geographically divergent human...
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