Article

Distance from Sub-Saharan Africa Predicts Mutational Load in Diverse Human Genomes

2015-05-22

Abstract excerpt

The Out-of-Africa (OOA) dispersal ~50,000 years ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase of mutational load in populations undergoing serial founder effects during range expansions. To test this hypothesis, we have sequenced full genomes and high-coverage exomes from 7 geographically divergent human popula...

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Literature Corpus work: 0403efdf-a338-55e4-b4ee-b4ba51196bf8
DOI: 10.1101/019711

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