Article

Altered immunity to microbiota, B cell activation and depleted γδ / resident memory T cells in colorectal cancer

2021-02-19

Abstract excerpt

We sought methods of rectifying microbiota:immune dysregulation as a route to prophylaxis and improved immunotherapy of colorectal cancer (CRC). CRC develops in gut epithelium, accompanied by low level inflammatory signaling, intestinal microbial dysbiosis and immune dysfunction. We examined populations of intraepithelial lymphocytes in non-affected colonic mucosa of CRC and healthy donors and circulating immune m...

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Literature Corpus work: 211f97b4-aa43-5cde-8813-3e1ed40cf504
DOI: 10.1101/2021.02.15.21251750

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