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Article

CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells

2 Jul 2018

Abstract excerpt

Abstract The efficacy of T-cell therapy is inhibited by various tumor-associated immunosuppressive ligands and soluble factors. Such inhibitory signals turn specific T-cell signaling pathways on or off, impeding the anticancer functions of T cells. Many studies have focused on PD-1 or CTLA-4 blockade to invigorate T-cell functions through CD28/B7 signaling, but obtaining robust clinical outcomes remains...

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Identifiers

PMID: 29967261
DOI: 10.1158/0008-5472.can-18-0030

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