Qualitative modeling of signaling networks in replicative senescence by selecting optimal node and arc sets

Abstract excerpt

Signaling networks are an important tool of modern systems biology and drug development. Here, we present a new methodology to qualitatively model signaling networks by combining experimental data and prior knowledge about protein connectivity. Unlike other methods, our approach does not focus solely on selecting which reactions are involved but also on whether a protein is present. This allows the user to model m...

Topics

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• Algorithms
• Bioinformatics and Genomic Networks
• Computational Drug Discovery Methods
• Databases, Protein
• ErbB Receptors
• Gene Regulatory Networks
• Models, Biological
• Signal Transduction

Identifiers and source

Literature Corpus work

89cd77e5-5737-5e5c-bc2d-6b9e8770014c

DOI

10.1101/389692