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Article

Static network structure can be used to model the phenotypic effects of perturbations in regulatory networks.

Bioinformatics (Oxford, England) - 1 Nov 2012

Feiglin Ariel, Hacohen Adar, Sarusi Avital, Fisher Jasmin, Unger Ron, Ofran Yanay

Abstract excerpt

MOTIVATION: Biological processes are dynamic, whereas the networks that depict them are typically static. Quantitative modeling using differential equations or logic-based functions can offer quantitative predictions of the behavior of biological systems, but they require detailed experimental characterization of interaction kinetics, which is typically unavailable. To determine to what extent complex biological...

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PMID: 22923292
DOI: 10.1093/bioinformatics/bts517

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EGFR
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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