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Article

Conceptual and computational framework for logical modelling of biological networks deregulated in diseases.

Briefings in bioinformatics - 19 Jul 2019

Montagud Arnau, Traynard Pauline, Martignetti Loredana, Bonnet Eric, Barillot Emmanuel, Zinovyev Andrei, Calzone Laurence

Abstract excerpt

Mathematical models can serve as a tool to formalize biological knowledge from diverse sources, to investigate biological questions in a formal way, to test experimental hypotheses, to predict the effect of perturbations and to identify underlying mechanisms. We present a pipeline of computational tools that performs a series of analyses to explore a logical model's properties. A logical model of initiation of...

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PMID: 29237040
DOI: 10.1093/bib/bbx163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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