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Article

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2020

An Sugyun, Cho Si-Young, Kang Junsoo, Lee Soobeom, Kim Hyung-Su, Min Dae-Jin, Son EuiDong, Cho Kwang-Hyun

Abstract excerpt

Cellular senescence is defined as a stable, persistent arrest of cell proliferation. Here, we examine whether senescent cells can lose senescence hallmarks and reenter a reversible state of cell-cycle arrest (quiescence). We constructed a molecular regulatory network of cellular senescence based on previous experimental evidence. To infer the regulatory logic of the network, we performed phosphoprotein array...

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Identifiers

PMID: 33229519
DOI: 10.1073/pnas.1920338117
PMCID: PMC7733858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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