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Article

Engineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography.

Human gene therapy - 1 Apr 2007

Koerber James T, Jang Jae-Hyung, Yu Julie H, Kane Ravi S, Schaffer David V

Abstract excerpt

Adeno-associated virus (AAV) is a promising vehicle for gene therapy, which will rely on the generation of high-titer, high-purity recombinant vectors. However, numerous purification protocols can involve challenging optimization or scalability issues, and most AAV serotypes do not bind heparin or sialic acid, used for AAV2/3 or AAV4/5 purification, requiring the development of new chromatography strategies....

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Identifiers

PMID: 17437357
DOI: 10.1089/hum.2006.139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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