Back to search

Article

Impact of 3-dimensional genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

2019-03-14

Abstract excerpt

<h4>Background</h4> Sex differences in the transcriptome and epigenome are widespread in mouse liver and are associated with sex-bias in liver disease. Several thousand sex-differential distal enhancers have been identified; however, their links to sex-biased genes and the impact of any sex-differences in nuclear organization, DNA looping, and chromatin interactions are unknown. <h4>Results</h4> To address these...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
899f6676-9ee7-5df1-903f-679826574dcc
DOI
10.1101/577577
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Impact of 3-dimensional genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liverDOI 10.1101/577577
Three-dimensional Genome Structure Reveals Distinct Chromatin Signatures of Mouse Female Germline Stem Cells During DevelopmentSemantic proximity
Single Nucleus MultiOmics Links Novel Transcription Factor Motifs to Murine Hepatic Sex Differences in Chromatin Accessibility and Metabolic Dysfunction-Associated Steatotic Liver DiseaseSemantic proximity
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred miceSemantic proximity
Genome-wide and parental allele-specific analysis of CTCF and cohesin DNA binding in mouse brain reveals a tissue-specific binding pattern and an association with imprinted differentially methylated regions.Semantic proximity
Harnessing natural variation to identify <i>cis</i> regulators of sex-biased gene expression in a multi-strain mouse liver modelSemantic proximity
Global Analysis of Expression, Maturation and Subcellular Localization of Mouse Liver Transcriptome Identifies Novel Sex-biased and TCPOBOP-responsive Long Non-coding RNAsSemantic proximity
Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.Semantic proximity
Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory LandscapesSemantic proximity
Sex-specific multi-level 3D genome dynamics in the mouse brainSemantic proximity
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice.Semantic proximity
Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion MachinerySemantic proximity
Offspring production of ovarian organoids derived from spermatogonial stem cells by chromatin reorganizationSemantic proximity
Select a neighboring publication to make it the new centre.