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Article

Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes

1 Feb 2017

Abstract excerpt

The mammalian sperm genome is thought to lack substantial information for the regulation of future expression after fertilization. Here, we show that most promoters in mouse sperm are flanked by well-positioned nucleosomes marked by active histone modifications. Analysis of these modifications suggests that many enhancers and super-enhancers functional in embryonic and adult tissues are already specified in...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 28178516
DOI: 10.1016/j.celrep.2017.01.034

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