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Article

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2021

Yadav Prem Swaroop, Feng Shuhao, Cong Qian, Kim Hanjun, Liu Yuchen, Yang Yingzi

Abstract excerpt

Job syndrome is a rare genetic disorder caused by STAT3 mutations and primarily characterized by immune dysfunction along with comorbid skeleton developmental abnormalities including osteopenia, recurrent fracture of long bones, and scoliosis. So far, there is no definitive cure for the skeletal defects in Job syndrome, and treatments are limited to management of clinical symptoms only. Here, we have investigated...

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Identifiers

PMID: 34172578
DOI: 10.1073/pnas.2020100118
PMCID: PMC8256036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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