Article

CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1

2022-01-06

Abstract excerpt

Sterile α motif (SAM) and HD domain-containing protein 1 (SAMHD1) is a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4 + T cells. As a dNTP triphosphate triphosphohydrolase (dNTPase), SAMHD1 is proposed to limit cellular dNTP levels correlating with inhibition of HIV-1 reverse transcription. The anti-viral activity of SAMHD1 is regulated by dephosphorylation of th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 898fa196-3478-5570-b97b-78d6ba286c5c
DOI: 10.1101/2022.01.04.475018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1DOI 10.1101/2022.01.04.475018Read

Gene editing of <i>SAMHD1</i> in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levelsSemantic proximity Read

Phosphorylation of murine SAMHD1 regulates its antiretroviral activitySemantic proximity Read

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.Semantic proximity Read

SAMHD1’s protein expression profile in humansSemantic proximity Read

SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4 <sup>+</sup> T-cellsSemantic proximity Read

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.Semantic proximity Read

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammationSemantic proximity Read

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+T-cellsSemantic proximity Read

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cellsSemantic proximity Read

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesSemantic proximity Read

SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase InhibitionSemantic proximity Read

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylationSemantic proximity Read