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Article

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity

1 Dec 2015

Abstract excerpt

BACKGROUND: Human SAMHD1 is a triphosphohydrolase that restricts the replication of retroviruses, retroelements and DNA viruses in noncycling cells. While modes of action have been extensively described for human SAMHD1, only little is known about the regulation of SAMHD1 in the mouse. Here, we characterize the antiviral activity of murine SAMHD1 with the help of knockout mice to shed light on the regulation and...

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PMID: 26667483
DOI: 10.1186/s12977-015-0229-6

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