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Article

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+T-cells

23 Oct 2012

Abstract excerpt

Resting CD4+ T-cells are critical for establishing HIV-1 reservoirs. It has been known for over two decades that resting CD4+ T-cells are refractory to HIV-1 infection, but the underlying mechanisms are not fully understood. Compared with activated CD4+ T-cells that support HIV-1 infection, resting CD4+ T-cells have lower levels of dNTPs, which limit HIV-1 reverse transcription. The dNTPase SAMHD1 has been...

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PMID: 23092163
DOI: 10.1186/1742-4690-9-88

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