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Article

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

12 Feb 2012

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22327569
DOI: 10.1038/ni.2236

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesPMID 22327569Read ↗

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammationSemantic proximity Read ↗

Nucleotide embargo by SAMHD1: A strategy to block retroviral infectionSemantic proximity Read ↗

SAMHD1 restricts HIV-1 infection in resting CD4+ T cellsSemantic proximity Read ↗

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cellsSemantic proximity Read ↗

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levelsSemantic proximity Read ↗

SAMHD1 Functions and Human Diseases.Semantic proximity Read ↗

SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferationSemantic proximity Read ↗

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.Semantic proximity Read ↗

Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1Semantic proximity Read ↗

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV InfectionSemantic proximity Read ↗

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).Semantic proximity Read ↗

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+T-cellsSemantic proximity Read ↗

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