Article
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Nature medicine - 1 Aug 2014
Ryoo Jeongmin, Choi Jongsu, Oh Changhoon, Kim Sungchul, Seo Minji, Kim Seok-Young, Seo Daekwan, Kim Jongkyu, White Tommy E, Brandariz-Nuñez Alberto, Diaz-Griffero Felipe, Yun Cheol-Heui, Hollenbaugh Joseph A, Kim Baek, Baek Daehyun, Ahn Kwangseog
Abstract excerpt
The HIV-1 restriction factor SAM domain- and HD domain-containing protein 1 (SAMHD1) is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool. However, phosphorylation of SAMHD1 regulates its ability to restrict HIV-1 without decreasing cellular dNTP levels, which is not consistent with a role for SAMHD1 dNTPase activity in HIV-1 restriction. Here, we show that SAMHD1 possesses RNase...
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