Article

SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4 <sup>+</sup> T-cells

2018-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts human immunodeficiency virus type 1 (HIV-1) replication in non-dividing cells by degrading intracellular deoxynucleoside triphosphates (dNTPs). SAMHD1 is highly expressed in resting CD4 + T-cells that are important for the HIV-1 reservoir and viral latency; however, whether SAMHD1 affects HIV-1 latency is unknown. Recombi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5dcfdedd-681e-5b8a-b307-8b045ca845a8
DOI: 10.1101/270843

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4 <sup>+</sup> T-cellsDOI 10.1101/270843Read

SAMHD1’s protein expression profile in humansSemantic proximity Read

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral ResponseSemantic proximity Read

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+T-cellsSemantic proximity Read

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.Semantic proximity Read

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV InfectionSemantic proximity Read

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathwaysSemantic proximity Read

SAMHD1 restricts HIV-1 infection in resting CD4+ T cellsSemantic proximity Read

SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB ActivationSemantic proximity Read

Gene editing of <i>SAMHD1</i> in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levelsSemantic proximity Read

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30aSemantic proximity Read

SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase InhibitorsSemantic proximity Read

SAMHD1 Functions and Human Diseases.Semantic proximity Read