Article
SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.
Nature communications - 28 Jul 2021
Martinat Charlotte, Cormier Arthur, Tobaly-Tapiero Joëlle, Palmic Noé, Casartelli Nicoletta, Mahboubi Bijan, Coggins Si'Ana A, Buchrieser Julian, Persaud Mirjana, Diaz-Griffero Felipe, Espert Lucile, Bossis Guillaume, Lesage Pascale, Schwartz Olivier, Kim Baek, Margottin-Goguet Florence, Saïb Ali, Zamborlini Alessia
Abstract excerpt
SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates. Yet, phosphorylation of T592 downregulates SAMHD1 antiviral activity, but not its dNTPase function, implying that additional mechanisms contribute to viral restriction. Here, we show that SAMHD1 is SUMOylated on residue K595, a modification...
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