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Article

Joint effect of polysocial risk score, lifestyle and genetic susceptibility with the risk of dementia: A prospective cohort study.

Journal of affective disorders - 1 Feb 2025

Yang Lichao, Sun Ziqing, He Qida, Zhu Maosheng, Sun Mengtong, Zhao Hanqing, Wang Yu, Li Jianing, Shi Yujie, Lou Zexin, Liu Boyan, Jiang Miao, Shen Yueping

Abstract excerpt

OBJECTIVES: The comprehensive impact of polysocial risk score (PsRS)-encompassing multiple social determinants of health (SDoHs) with genetic and lifestyle factors on dementia incidence remains to be elucidated. STUDY DESIGN: This study aimed to clear the associations between PsRS and dementia incidence and evaluated how genetic and lifestyle factors modified these associations in the UK Biobank cohort. METHODS:...

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PMID: 39505019
DOI: 10.1016/j.jad.2024.11.005

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