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Article

Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice.

Journal of molecular and cellular cardiology - 1 Aug 2021

Gao Mengru, Han Jing, Zhu Yifei, Tang Chunlei, Liu Liangliang, Xiao Wang, Ma Xin

Abstract excerpt

Obesity induces inflammation and oxidative stress, and ultimately leads to vasodilatory dysfunction in which Transient receptor potential vanilloid type 4 (TRPV4) and Nicotinamide Adenine Dinucleotide Phosphate Oxidase (Nox2) have been reported to be involved. However, little attention has been paid to the role of the TRPV4-Nox2 complex in these problems. The purpose of this study was to figure out the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33932464
DOI: 10.1016/j.yjmcc.2021.04.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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