Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure.

American journal of physiology. Heart and circulatory physiology - 1 May 2016

Yap Fui C, Weber David S, Taylor Mark S, Townsley Mary I, Comer Brian S, Maylie James, Adelman John P, Lin Mike T

Abstract excerpt

Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation via an endothelium-derived hyperpolarization (EDH) pathway. Although the activation of SK3 and IK1 channels converges on EDH, their subcellular effects on signal transduction are different and not completely clear. In this study, a novel endothelium-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Membrane Microdomains

Share to Membrane Potentials

Share to Small-Conductance Calcium-Activated Potassium Channels

Share to TRPV Cation Channels

Share to Vasodilation

Source

Open in PubMed Open full text

Identifiers

PMID: 26945080
DOI: 10.1152/ajpheart.00787.2015
PMCID: PMC4867388

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure.PMID 26945080Read ↗

Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.Semantic proximity Read ↗

Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.Semantic proximity Read ↗

Aging affects K <sub>V</sub> 7 channels and perivascular-adipose tissue-mediated vascular toneSemantic proximity Read ↗

Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension.Semantic proximity Read ↗

Role of Ion Channel Remodeling in Endothelial Dysfunction Induced by Pulmonary Arterial HypertensionSemantic proximity Read ↗

Disruption of Physiological Balance Between Nitric Oxide and Endothelium-Dependent Hyperpolarization Impairs Cardiovascular Homeostasis in Mice.Semantic proximity Read ↗

Kv1.3 K<sup>+</sup>Channel Physiology Assessed by Genetic and Pharmacological ModulationSemantic proximity Read ↗

Connexins: Key Players in the Control of Vascular Plasticity and Function.Semantic proximity Read ↗

TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.Semantic proximity Read ↗

Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.Semantic proximity Read ↗

Potassium channels in pulmonary arterial hypertension.Semantic proximity Read ↗

An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.