Article

Endothelial LRRC8C associates with LRRC8A and LRRC8B to regulate vascular reactivity and blood pressure

2025-08-20

Abstract excerpt

Vascular tone is impacted by the endothelium’s ability to detect mechanical and chemical stimulation. L eucine- R ich R epeat- C ontaining protein 8 A, (LRRC8A), was previously identified as a required component of the mechanoresponsive endothelial LRRC8 complex regulating AKT-endothelial nitric oxide synthase (eNOS) signaling and vascular function. While LRRC8A is broadly expressed, LRRC8B, C, D and E have t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fb5b8b4-ba6c-5b0f-9caa-edf025f57bdd
DOI: 10.1101/2025.08.17.670763

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endothelial LRRC8C associates with LRRC8A and LRRC8B to regulate vascular reactivity and blood pressureDOI 10.1101/2025.08.17.670763Read

Endothelial function and dysfunction in the cardiovascular system: the long non-coding roadSemantic proximity Read

Dissecting the Cellular Genetics of Cardiovascular Disease Through Endothelial and Immune Compartments ProfilingSemantic proximity Read

Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)Semantic proximity Read

Regulatory mechanisms in multiple vascular diseases locus <i>LRP1</i> involve repression by SNAIL and extracellular matrix remodelingSemantic proximity Read

Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery diseaseSemantic proximity Read

Sex-Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction.Semantic proximity Read

CXCL12: A New Player in Coronary Disease Identified through Human GeneticsSemantic proximity Read

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.Semantic proximity Read

LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis.Semantic proximity Read

NR4A1 contributes to high-fat associated endothelial dysfunction by promoting CaMKII-Parkin-mitophagy pathwaysSemantic proximity Read

Integrative functional genomics analysis identifies pleiotropic genes for vascular diseases.Semantic proximity Read

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammationSemantic proximity Read