Article

Pan-cancer tumor classification by a holistic tumor microenvironment atlas

2025-12-27

Abstract excerpt

The tumor microenvironment (TME) heterogeneity presents a major bottleneck to effective cancer immunotherapies. We address this by establishing a pan-cancer tumor classification system based on the holistic TME cellular components. First, using single-cell transcriptomes from 1,271 patients across 26 cancer types, we compile a TME cellular atlas, leading to the identification of recurrent cell states and multicell...

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Literature Corpus work: 076791cd-bf4c-5c95-9ae6-5eb9dbb2d84f
DOI: 10.64898/2025.12.27.696641

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