Article

CD40 agonism enhances immune checkpoint blockade and generates immunologic memory via CD4+ T cells in ERα+ mammary tumors

2025-06-16

Abstract excerpt

<title>Abstract</title> There has been marked improvement in the clinical outcome of triple-negative breast cancer (TNBC) with the use of immune checkpoint blockade (ICB) although serious immune-related adverse effects are not uncommon. Unlike TNBC, ERα + breast tumors are largely unresponsive to ICB. Here we demonstrate defective priming by cross-presenting conventional dendritic cells (cDCs) and a blunted re...

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Literature Corpus work: 895935c8-3a41-55e7-8eab-c2d1d61098ca
DOI: 10.21203/rs.3.rs-6823527/v1

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