Article

Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells

2019-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Estrogen receptor (ER)-positive breast tumors are routinely treated with estrogen-depriving therapies. Despite their effectiveness, patients often progress into a more aggressive form of the disease. Through a chemical screen oriented to identify chemicals capable of inducing the expression of the immune-checkpoint ligand PD-L1, we found antiestrogens as hits. Subsequent validations confirmed th...

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Literature Corpus work: 24b89935-f210-5e96-a9e7-20d5943df411
DOI: 10.1101/715136

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