Article

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy

2025-09-20

Abstract excerpt

Immunotherapies have revolutionized cancer care in recent decades, but approved therapies often fail and currently only target specific steps in the generation of anti-cancer immune responses. Notably, the majority of approved immunotherapies do not target antigen processing and presentation, which are key steps in the development of immune responses and harbor potential as targets to improve immunotherapy. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 827454ce-0bfa-567c-a30c-6f735f0e32e5
DOI: 10.1101/2025.09.17.676884

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapyDOI 10.1101/2025.09.17.676884Read

CD40 agonism enhances immune checkpoint blockade and generates immunologic memory via CD4+ T cells in ERα+ mammary tumorsSemantic proximity Read

Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapySemantic proximity Read

Tregs constrain CD8 <sup>+</sup> T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapySemantic proximity Read

From Metastatic Gateways to Immune Reservoirs: Reframing Tumor-Draining Lymph Nodes in Perioperative Cancer ImmunotherapySemantic proximity Read

Tumor MHCII immunity requires in situ antigen presentation by cancer-associated fibroblasts.Semantic proximity Read

Rewiring dendritic cell function with CLEC9A and DEC205-based chimeric antigen receptorsSemantic proximity Read

An anti-cancer cell therapy platform utilizing ex vivo physiologic dendritic cells expressing mRNA-encoded antigens and immune checkpoint blockersSemantic proximity Read

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response.Semantic proximity Read

Covalent tumor anchoring spatially orchestrates antitumor immunitySemantic proximity Read

Improved dendritic cell therapy for cancer by enhancing in vivo lymph node migration using a novel chemokine-based sorting methodSemantic proximity Read

Refining Dendritic Cell-Based Cancer Vaccines: Subset Targeting, Translational Barriers, and Emerging StrategiesSemantic proximity Read

Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunitySemantic proximity Read