Article

Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors

2022-11-04

Abstract excerpt

<title>Abstract</title> <p>Radiation therapy (RT) increases tumor response to CTLA-4 inhibition (CTLA4i) in mice and in some patients, yet deep responses are rare. This raises the possibility that effector T cells are insufficiently activated by the combination. To address this question we use mouse models of triple negative breast cancer highly resistant to immunotherapy. We find that CTLA4i promotes the expansi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58e35254-4ff2-5549-83b8-aaaf27369b13
DOI: 10.21203/rs.3.rs-2227333/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumorsDOI 10.21203/rs.3.rs-2227333/v1Read

B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer.Semantic proximity Read

A single-cell transcriptomic landscape of innate and adaptive intratumoral immunity in triple negative breast cancer during chemo- and immunotherapiesSemantic proximity Read

Murine models for triple-negative breast cancer with differential responsiveness to immunotherapySemantic proximity Read

Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancerSemantic proximity Read

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast CancersSemantic proximity Read

Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironmentSemantic proximity Read

Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine triple-negative breast cancerSemantic proximity Read

CD4+ T-Cells Drive Triple Negative Breast Cancer Recurrence via Non-Canonical TGFβ SignalingSemantic proximity Read

Early clonal expansion of tumor-infiltrating lymphocytes predicts response to immune checkpoint therapySemantic proximity Read

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.Semantic proximity Read

CD40 agonism enhances immune checkpoint blockade and generates immunologic memory via CD4+ T cells in ERα+ mammary tumorsSemantic proximity Read

A conserved subset of cold tumors responsive to immune checkpoint blockadeSemantic proximity Read