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Article

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells.

Cancer immunology research - 1 Feb 2016

Van Lint Sandra, Renmans Dries, Broos Katrijn, Goethals Lode, Maenhout Sarah, Benteyn Daphné, Goyvaerts Cleo, Du Four Stephanie, Van der Jeught Kevin, Bialkowski Lukasz, Flamand Véronique, Heirman Carlo, Thielemans Kris, Breckpot Karine

Abstract excerpt

Modulating the activity of tumor-infiltrating dendritic cells (TiDC) provides opportunities for novel cancer interventions. In this article, we report on our study of the uptake of mRNA by CD8α(+) cross-presenting TiDCs upon its intratumoral (i.t.) delivery. We exploited this property to deliver mRNA encoding the costimulatory molecule CD70, the activation stimuli CD40 ligand, and constitutively active Toll-like...

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Identifiers

PMID: 26659303
DOI: 10.1158/2326-6066.CIR-15-0163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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