Article

Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition

2023-01-13

Abstract excerpt

G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR signaling complex formation, but a mechanism for this role is not understood. Using NMR spectroscopy, we visualized the impact of anionic lipids on the function-related conformational equilibria of the human A 2A adenosine receptor (A 2A AR) in bi...

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Literature Corpus work: 894e902c-8dfc-58d2-9a51-d2f9af2e40d4
DOI: 10.1101/2023.01.11.523010

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