Article
Developmental and temporal characteristics of clonal sperm mosaicism.
Cell - 2 Sept 2021
Yang Xiaoxu, Breuss Martin W, Xu Xin, Antaki Danny, James Kiely N, Stanley Valentina, Ball Laurel L, George Renee D, Wirth Sara A, Cao Beibei, Nguyen An, McEvoy-Venneri Jennifer, Chai Guoliang, Nahas Shareef, Van Der Kraan Lucitia, Ding Yan, Sebat Jonathan, Gleeson Joseph G
Abstract excerpt
Throughout development and aging, human cells accumulate mutations resulting in genomic mosaicism and genetic diversity at the cellular level. Mosaic mutations present in the gonads can affect both the individual and the offspring and subsequent generations. Here, we explore patterns and temporal stability of clonal mosaic mutations in male gonads by sequencing ejaculated sperm. Through 300× whole-genome...
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