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Article

Selective mutation accumulation: a computational model of the paternal age effect.

Bioinformatics (Oxford, England) - 15 Dec 2016

Whelan Eoin C, Nwala Alexander C, Osgood Christopher, Olariu Stephan

Abstract excerpt

MOTIVATION: As the mean age of parenthood grows, the effect of parental age on genetic disease and child health becomes ever more important. A number of autosomal dominant disorders show a dramatic paternal age effect due to selfish mutations: substitutions that grant spermatogonial stem cells (SSCs) a selective advantage in the testes of the father, but have a deleterious effect in offspring. In this paper we...

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Source

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PMID: 27531106
DOI: 10.1093/bioinformatics/btw528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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