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Article

Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans.

PloS one - 1 Jan 2013

Mosbech Mai-Britt, Kruse Rikke, Harvald Eva Bang, Olsen Anne Sofie Braun, Gallego Sandra Fernandez, Hannibal-Bach Hans Kristian, Ejsing Christer S, Færgeman Nils J

Abstract excerpt

Ceramide and its metabolites constitute a diverse group of lipids, which play important roles as structural entities of biological membranes as well as regulators of cellular growth, differentiation, and development. The C. elegans genome comprises three ceramide synthase genes; hyl-1, hyl-2, and lagr-1. HYL-1 function is required for synthesis of ceramides and sphingolipids containing very long acyl-chains...

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PMID: 23894595
DOI: 10.1371/journal.pone.0070087
PMCID: PMC3716707

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