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Article

Fat Metabolism Links Germline Stem Cells and Longevity in <i>C. elegans</i>

6 Nov 2008

Abstract excerpt

Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans, which in turn regulates longevity. GSC arrest promotes systemic lipolysis via induction of a specific fat lipase. Subsequently, fat mobilization is promoted and...

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PMID: 18988854
DOI: 10.1126/science.1162011

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