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Article

DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.

PLoS genetics - 1 Feb 2016

Amrit Francis Raj Gandhi, Steenkiste Elizabeth Marie, Ratnappan Ramesh, Chen Shaw-Wen, McClendon T Brooke, Kostka Dennis, Yanowitz Judith, Olsen Carissa Perez, Ghazi Arjumand

Abstract excerpt

Elimination of the proliferating germline extends lifespan in C. elegans. This phenomenon provides a unique platform to understand how complex metazoans retain metabolic homeostasis when challenged with major physiological perturbations. Here, we demonstrate that two conserved transcription regulators essential for the longevity of germline-less adults, DAF-16/FOXO3A and TCER-1/TCERG1, concurrently enhance the...

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Source

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Identifiers

PMID: 26862916
DOI: 10.1371/journal.pgen.1005788
PMCID: PMC4749232

Genes

TCERG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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