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C-terminal cysteines of HRas control Erk signaling and 15-deoxy-Δ <sup>12,14</sup> -prostaglandin J <sup>2</sup> (15d-PGJ <sup>2</sup> ) mediated inhibition of myoblast differentiation

2023-05-22

Abstract excerpt

HRas is an important node that controls cellular signaling, proliferation, and differentiation. Mutants of HRas (e.g., the constitutively active HRas V12) can be oncogenic, and can also inhibit myoblast differentiation. The C-terminal cysteines of HRas (Cys181 and Cys184) serve as substrates for intra-cellular reversible palmitoylation and de-palmitoylation reactions, which control its subcellular distribution. Th...

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Literature Corpus work
8929f42f-a0ab-50ed-a9d0-5bf225fd409e
DOI
10.1101/2023.05.20.541575
Open publication

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C-terminal cysteines of HRas control Erk signaling and 15-deoxy-Δ <sup>12,14</sup> -prostaglandin J <sup>2</sup> (15d-PGJ <sup>2</sup> ) mediated inhibition of myoblast differentiationDOI 10.1101/2023.05.20.541575
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