Article
Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus.
Experimental cell research - 10 Dec 2003
Brede Gaute, Solheim Jorun, Stang Espen, Prydz Hans
Abstract excerpt
We have dissected the molecular determinants involved in targeting the protein serine kinase PSKH1 to the endoplasmic reticulum (ER), the Golgi apparatus, and the plasma membrane (PM). Given this intracellular localization pattern, a potential role of PSKH1 in the secretory pathway was explored. The amino-terminal of PSKH1 revealed a striking similarity to the often acylated Src homology domain 4 (SH4)-harboring...
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