Article
The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2020
Werner Ernst R, Keller Markus A, Sailer Sabrina, Lackner Katharina, Koch Jakob, Hermann Martin, Coassin Stefan, Golderer Georg, Werner-Felmayer Gabriele, Zoeller Raphael A, Hulo Nicolas, Berger Johannes, Watschinger Katrin
Abstract excerpt
A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell membranes. A decline in these lipids has been observed in such diseases as Alzheimer's and chronic obstructive pulmonary disease. Plasmalogens contain a characteristic 1-O-alk-1'-enyl ether (vinyl ether) double bond that confers special biophysical, biochemical, and...
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