Article

Immunological liver-skin axis: a systemic Vγ4 <sup>+</sup> γδT17 cell response links psoriasis-like inflammation and MASLD

2025-12-23

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) and psoriasis frequently co-occur and share interleukin-17 (IL-17)-mediated inflammatory mechanisms. Using a murine model combining Western-diet-induced early MASLD with chronic imiquimod-triggered psoriasis-like dermatitis, we observed exacerbated skin inflammation with increased cellularity and systemic IL-17–driven immune activation. In mice with...

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Literature Corpus work: 7f07c3d4-db7b-5acf-a307-c551ff9e1ac2
DOI: 10.64898/2025.12.22.695890

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