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Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins

11 Jan 2022

Abstract excerpt

Cholesterol is a critical lipid for all mammalian cells, ensuring proper membrane integrity, fluidity, and biochemical function. Accumulating evidence indicates that macrophages rapidly and profoundly reprogram their cholesterol metabolism in response to activation signals to support host defense processes. However, our understanding of the molecular details underlying how and why cholesterol homeostasis is...

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PMID: 35017717
DOI: 10.1038/s41423-021-00827-0

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