Article
Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival
13 Sept 2019
Abstract excerpt
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis of multiple lymphomas. Yet, knowledge of how EBV subverts host biosynthetic pathways to transform resting lymphocytes into activated lymphoblasts remains incomplete. Using a temporal proteomic dataset of EBV primary human B-cell...
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