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Article

Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity.

Acta neuropathologica communications - 31 Jan 2015

Stewart Tessandra, Sossi Vesna, Aasly Jan O, Wszolek Zbigniew K, Uitti Ryan J, Hasegawa Kazuko, Yokoyama Teruo, Zabetian Cyrus P, Leverenz James B, Stoessl Alexander Jon, Wang Yu, Ginghina Carmen, Liu Changqin, Cain Kevin C, Auinger Peggy, Kang Un Jung, Jensen Poul Henning, Shi Min, Zhang Jing

Abstract excerpt

INTRODUCTION: α-Synuclein (α-syn) is a key protein in Parkinson's disease (PD), and one of its phosphorylated forms, pS129, is higher in PD patients than healthy controls. However, few studies have examined its levels in longitudinally collected cerebrospinal fluid (CSF) or in preclinical cases. In this study, CSF and clinical data were contributed by >300 subjects from three cohorts (the longitudinal DATATOP...

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PMID: 25637461
DOI: 10.1186/s40478-015-0185-3
PMCID: PMC4362824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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