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Article

Genetic diversity of Collaborative Cross mice controls viral replication, clinical severity and brain pathology induced by Zika virus infection, independently of <i>Oas1b</i>

2019-06-21

Abstract excerpt

<h4>ABSTRACT</h4> The explosive spread of Zika virus (ZIKV) has been associated with major variations in severe disease and congenital afflictions among infected populations, suggesting an influence of host genes. We investigated how genome-wide variants could impact susceptibility to ZIKV infection in mice. We first describe that the susceptibility of Ifnar1 knockout mice is largely influenced by their genetic...

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Literature Corpus work
89196acd-7b6d-54a8-bf91-1beb5eb29d9e
DOI
10.1101/677484
Open publication

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Genetic diversity of Collaborative Cross mice controls viral replication, clinical severity and brain pathology induced by Zika virus infection, independently of <i>Oas1b</i>DOI 10.1101/677484
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