Article

Zika virus infection in Collaborative Cross mice

2019-07-08

Abstract excerpt

The 2015-2016 emergence of Zika virus (ZIKV) in the Americas, and recognition that ZIKV infection during pregnancy can result in birth defects, revealed a need for small animal models to study ZIKV pathogenic mechanisms and evaluate candidate vaccines and antivirals. Mice would be an attractive system for such studies, but ZIKV replicates poorly in laboratory mice because it fails to antagonize murine STAT2 and ST...

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Literature Corpus work: 673fa6b8-6c61-56d2-96f7-125b53d3b79c
DOI: 10.1101/695510

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