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Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by <i>Irf3</i> deficiency <i>in vitro</i> but requires other variants <i>in vivo</i> , not linked to the type I interferon response

2023-03-30

Abstract excerpt

Zika virus (ZIKV) is a Flavivirus responsible for recent epidemics in Pacific Islands and in the Americas. In humans, the consequences of ZIKV infection range from asymptomatic infection to severe neurological disease such as Guillain-Barré syndrome or fetal neurodevelopmental defects, suggesting, among other factors, the influence of host genetic variants. We previously reported similar diverse outcomes of ZIKV i...

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Literature Corpus work
0c7b8ffe-3919-527e-8b0e-30a0d2bb4799
DOI
10.1101/2023.03.27.534491
Open publication

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Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by <i>Irf3</i> deficiency <i>in vitro</i> but requires other variants <i>in vivo</i> , not linked to the type I interferon responseDOI 10.1101/2023.03.27.534491
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