Article
Functional Genomics and Immunologic Tools: The Impact of Viral and Host Genetic Variations on the Outcome of Zika Virus Infection.
Viruses - 11 Aug 2018
Yun Sang-Im, Song Byung-Hak, Frank Jordan C, Julander Justin G, Olsen Aaron L, Polejaeva Irina A, Davies Christopher J, White Kenneth L, Lee Young-Min
Abstract excerpt
Zika virus (ZIKV) causes no-to-mild symptoms or severe neurological disorders. To investigate the importance of viral and host genetic variations in determining ZIKV infection outcomes, we created three full-length infectious cDNA clones as bacterial artificial chromosomes for each of three spatiotemporally distinct and genetically divergent ZIKVs: MR-766 (Uganda, 1947), P6-740 (Malaysia, 1966), and PRVABC-59...
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