Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two Genetic Differences between Closely Related Zika Virus Strains Determine Pathogenic Outcome in Mice.

Journal of virology - 29 Sept 2020

Carbaugh Derek L, Zhou Shuntai, Sanders Wes, Moorman Nathaniel J, Swanstrom Ronald, Lazear Helen M

Abstract excerpt

Recent Zika virus (ZIKV) outbreaks and unexpected clinical manifestations of ZIKV infection have prompted an increase in ZIKV-related research. Here, we identify two strain-specific determinants of ZIKV virulence in mice. We found that strain H/PF/2013 caused 100% lethality in Ifnar1-/- mice, whereas PRVABC59 caused no lethality; both strains caused 100% lethality in Ifnar1-/-Ifngr1-/- double-knockout (DKO) mice....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon gamma Receptor

Share to Receptor, Interferon alpha-beta

Share to Receptors, Interferon

Share to Vero Cells

Share to Zika Virus

Share to Zika Virus Infection

Source

Open in PubMed Open full text

Identifiers

PMID: 32796074
DOI: 10.1128/JVI.00618-20
PMCID: PMC7527068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two Genetic Differences between Closely Related Zika Virus Strains Determine Pathogenic Outcome in Mice.PMID 32796074Read ↗

Genetic diversity of Collaborative Cross mice controls viral replication, clinical severity and brain pathology induced by Zika virus infection, independently of <i>Oas1b</i>Semantic proximity Read ↗

A natural polymorphism in Zika virus NS2A protein responsible of virulence in miceSemantic proximity Read ↗

An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.Semantic proximity Read ↗

Functional Genomics and Immunologic Tools: The Impact of Viral and Host Genetic Variations on the Outcome of Zika Virus Infection.Semantic proximity Read ↗

Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses.Semantic proximity Read ↗

Zika virus infection in Collaborative Cross miceSemantic proximity Read ↗

Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b.Semantic proximity Read ↗

Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) miceSemantic proximity Read ↗

Zika structural genes determine the virulence of African and Asian lineages.Semantic proximity Read ↗

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by <i>Irf3</i> deficiency <i>in vitro</i> but requires other variants <i>in vivo</i> , not linked to the type I interferon responseSemantic proximity Read ↗

A Reverse Genetics Platform That Spans the Zika Virus Family TreeSemantic proximity Read ↗

Characterization of Lethal Zika Virus Infection in AG129 MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.